Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel.
Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L. and cannabinoids and over 2,000 articles on endocannabinoids. The present review deals with the history of the Cannabis sativa L. plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Radula spp. In addition, details of the pharmacology of natural cannabinoids, as well as synthetic agonists and antagonists are presented. Finally, details regarding the pioneering isolation of the endocannabinoid anandamide, as well as the pharmacology and potential therapeutic uses of endocannabinoid congeners are presented. © 2008 Wiley Periodicals, Inc. Med Res Rev.
Australian New Crops Web Site
Supported by the Rural Industries Research and Development Corporation
Listing of Interesting Plants of the World
http://www.newcrops.uq.edu.au/listing/species_pages_C/Cannabis_sativa.htm
http://www.newcrops.uq.edu.au/listing/species_pages_C/Cannabis_indica.htm
http://www.newcrops.uq.edu.au/listing/species_pages_C/Cannabis_ruderalis.htm
http://www.beckleyfoundation.org/librarycontents.html
